abstract：:Serine protease cascades regulate important insect immune responses namely melanization and Toll pathway activation. An important component of these cascades are clip-domain serine protease homologs (cSPHs), which are non-catalytic, but essential for activating the enzyme prophenoloxidase (PPO) in the melanization res...

journal_title：PLoS pathogens

authors： El Moussawi L,Nakhleh J,Kamareddine L,Osta MA

更新日期：2019-11-25 00:00:00

abstract：:Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) is important for persistent infection in the host as well as viral oncogenesis. The replication and transcription activator (RTA) encoded by KSHV ORF50 plays a central role in the switch from viral latency to lytic replication. Given that RTA is a transcri...

journal_title：PLoS pathogens

authors： Wei X,Bai L,Dong L,Liu H,Xing P,Zhou Z,Wu S,Lan K

更新日期：2019-11-21 00:00:00

abstract：:The unfolded protein response (UPR) in the endoplasmic reticulum (ER) constitutes a critical component of host innate immunity against microbial infections. In this report, we show that porcine reproductive and respiratory syndrome virus (PRRSV) utilizes the UPR machinery for its own benefit. We provide evidence that ...

journal_title：PLoS pathogens

authors： Gao P,Chai Y,Song J,Liu T,Chen P,Zhou L,Ge X,Guo X,Han J,Yang H

更新日期：2019-11-18 00:00:00

abstract：:The human T cell leukemia virus HTLV-1 establishes a persistent infection in vivo in which the viral sense-strand transcription is usually silent at a given time in each cell. However, cellular stress responses trigger the reactivation of HTLV-1, enabling the virus to transmit to a new host cell. Using single-molecule...

journal_title：PLoS pathogens

authors： Miura M,Dey S,Ramanayake S,Singh A,Rueda DS,Bangham CRM

更新日期：2019-11-18 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00

abstract：:Viral late domains are used by many viruses to recruit the cellular endosomal sorting complex required for transport (ESCRT) to mediate membrane scission during viral budding. Unlike the P(S/T)AP and YPX(1-3)L late domains, which interact directly with the ESCRT proteins Tsg101 and ALIX, the molecular linkage connecti...

journal_title：PLoS pathogens

authors： Ziegler CM,Dang L,Eisenhauer P,Kelly JA,King BR,Klaus JP,Manuelyan I,Mattice EB,Shirley DJ,Weir ME,Bruce EA,Ballif BA,Botten J

更新日期：2019-11-11 00:00:00

abstract：:Eastern equine encephalitis virus (EEEV), a mosquito-borne RNA virus, is one of the most acutely virulent viruses endemic to the Americas, causing between 30% and 70% mortality in symptomatic human cases. A major factor in the virulence of EEEV is the presence of four binding sites for the hematopoietic cell-specific ...

journal_title：PLoS pathogens

authors： Trobaugh DW,Sun C,Bhalla N,Gardner CL,Dunn MD,Klimstra WB

更新日期：2019-10-28 00:00:00

abstract：:The viral replication proteins of plus-stranded RNA viruses orchestrate the biogenesis of the large viral replication compartments, including the numerous viral replicase complexes, which represent the sites of viral RNA replication. The formation and operation of these virus-driven structures require subversion of nu...

journal_title：PLoS pathogens

authors： Lin W,Liu Y,Molho M,Zhang S,Wang L,Xie L,Nagy PD

更新日期：2019-10-24 00:00:00

abstract：:Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells in LN of cART-suppre...

journal_title：PLoS pathogens

authors： Pino M,Paganini S,Deleage C,Padhan K,Harper JL,King CT,Micci L,Cervasi B,Mudd JC,Gill KP,Jean SM,Easley K,Silvestri G,Estes JD,Petrovas C,Lederman MM,Paiardini M

更新日期：2019-10-18 00:00:00

abstract：:Type I interferons (T1-IFN) are critical in the innate immune response, acting upon infected and uninfected cells to initiate an antiviral state by expressing genes that inhibit multiple stages of the lifecycle of many viruses. T1-IFN triggers the production of Interferon-Stimulated Genes (ISGs), activating an antivir...

journal_title：PLoS pathogens

authors： Parekh NJ,Krouse TE,Reider IE,Hobbs RP,Ward BM,Norbury CC

更新日期：2019-10-11 00:00:00

abstract：:The intracellular pathogen Listeria monocytogenes is distinguished by its ability to invade and replicate within mammalian cells. Remarkably, of the 15 serovars within the genus, strains belonging to serovar 4b cause the majority of listeriosis clinical cases and outbreaks. The Listeria O-antigens are defined by subtl...

journal_title：PLoS pathogens

authors： Sumrall ET,Shen Y,Keller AP,Rismondo J,Pavlou M,Eugster MR,Boulos S,Disson O,Thouvenot P,Kilcher S,Wollscheid B,Cabanes D,Lecuit M,Gründling A,Loessner MJ

更新日期：2019-10-07 00:00:00

abstract：:Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during influenza virus infec...

journal_title：PLoS pathogens

authors： Wei F,Jiang Z,Sun H,Pu J,Sun Y,Wang M,Tong Q,Bi Y,Ma X,Gao GF,Liu J

更新日期：2019-10-04 00:00:00

abstract：:Filariae are parasitic nematodes that are transmitted to their definitive host as third-stage larvae by arthropod vectors like mosquitoes. Filariae cause diseases including: lymphatic filariasis with distressing and disturbing symptoms like elephantiasis; and river blindness. Filarial diseases affect millions of peopl...

journal_title：PLoS pathogens

authors： Kashyap SS,Verma S,Voronin D,Lustigman S,Kulke D,Robertson AP,Martin RJ

更新日期：2019-09-25 00:00:00

abstract：:The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature is switched from 29°C at 37°...

journal_title：PLoS pathogens

authors： Lim XN,Shan C,Marzinek JK,Dong H,Ng TS,Ooi JSG,Fibriansah G,Wang J,Verma CS,Bond PJ,Shi PY,Lok SM

更新日期：2019-09-19 00:00:00

abstract：:Necrotrophic plant pathogens acquire nutrients from dead plant cells, which requires the disintegration of the plant cell wall and tissue structures by the pathogen. Infected plants lose tissue integrity and functional immunity as a result, exposing the nutrient rich, decayed tissues to the environment. One challenge ...

journal_title：PLoS pathogens

authors： Cui Z,Yang CH,Kharadi RR,Yuan X,Sundin GW,Triplett LR,Wang J,Zeng Q

更新日期：2019-08-05 00:00:00

abstract：:Human respiratory syncytial virus (RSV) is the leading viral cause of acute pediatric lower respiratory tract infections worldwide, with no available vaccine or effective antiviral drug. To gain insight into virus-host interactions, we performed a genome-wide siRNA screen. The expression of over 20,000 cellular genes ...

journal_title：PLoS pathogens

authors： Lingemann M,McCarty T,Liu X,Buchholz UJ,Surman S,Martin SE,Collins PL,Munir S

更新日期：2019-08-05 00:00:00

abstract：:Neisseria gonorrhoeae causes the sexually-transmitted infection gonorrhea, a global disease that is difficult to treat and for which there is no vaccine. This pathogen employs an arsenal of conserved outer membrane proteins called TonB-dependent transporters (TdTs) that allow the gonococcus to overcome nutritional imm...

journal_title：PLoS pathogens

authors： Maurakis S,Keller K,Maxwell CN,Pereira K,Chazin WJ,Criss AK,Cornelissen CN

更新日期：2019-08-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a ubiquitous pathogen that can cause disability in newborns and serious clinical diseases in immunocompromised patients. HCMV has a large genome with enormous coding potential; its viral particles are equipped with complicated glycoprotein complexes and can infect a wide range of human ...

journal_title：PLoS pathogens

authors： Ye X,Gui X,Freed DC,Ku Z,Li L,Chen Y,Xiong W,Fan X,Su H,He X,Rustandi RR,Loughney JW,Ma N,Espeseth AS,Liu J,Zhu H,Wang D,Zhang N,Fu TM,An Z

更新日期：2019-07-29 00:00:00

abstract：:T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms regulating HIV-1 transcription in lymph nodes (LNs) remain unclear. In...

journal_title：PLoS pathogens

authors： Banga R,Rebecchini C,Procopio FA,Noto A,Munoz O,Ioannidou K,Fenwick C,Ohmiti K,Cavassini M,Corpataux JM,de Leval L,Pantaleo G,Perreau M

更新日期：2019-07-22 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:The Pseudomonas syringae acetyltransferase HopZ1a is delivered into host cells by the type III secretion system to promote bacterial growth. However, in the model plant host Arabidopsis thaliana, HopZ1a activity results in an effector-triggered immune response (ETI) that limits bacterial proliferation. HopZ1a-triggere...

journal_title：PLoS pathogens

authors： Bastedo DP,Khan M,Martel A,Seto D,Kireeva I,Zhang J,Masud W,Millar D,Lee JY,Lee AH,Gong Y,Santos-Severino A,Guttman DS,Desveaux D

更新日期：2019-07-03 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV latent and lytic transcripts. F...

journal_title：PLoS pathogens

authors： Lang F,Singh RK,Pei Y,Zhang S,Sun K,Robertson ES

更新日期：2019-06-21 00:00:00

abstract：:G3BP-1 and -2 (hereafter referred to as G3BP) are multifunctional RNA-binding proteins involved in stress granule (SG) assembly. Viruses from diverse families target G3BP for recruitment to replication or transcription complexes in order to block SG assembly but also to acquire pro-viral effects via other unknown func...

journal_title：PLoS pathogens

authors： Götte B,Panas MD,Hellström K,Liu L,Samreen B,Larsson O,Ahola T,McInerney GM

更新日期：2019-06-14 00:00:00

abstract：:Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutio...

journal_title：PLoS pathogens

authors： Deeg CM,Zimmer MM,George EE,Husnik F,Keeling PJ,Suttle CA

更新日期：2019-05-31 00:00:00

abstract：:It has been proposed that in wild ecosystems viruses are often plant mutualists, whereas agroecosystems favour pathogenicity. We seek evidence for virus pathogenicity in wild ecosystems through the analysis of plant-virus coevolution, which requires a negative effect of infection on the host fitness. We focus on the i...

journal_title：PLoS pathogens

authors： Montes N,Alonso-Blanco C,García-Arenal F

更新日期：2019-05-28 00:00:00

abstract：:Clonorchis sinensis is a carcinogenic human liver fluke, prolonged infection which provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma (CCA). These effects are driven by direct physical damage caused by the worms, as well as chemical irritation from their excretory-s...

journal_title：PLoS pathogens

authors： Won J,Cho Y,Lee D,Jeon BY,Ju JW,Chung S,Pak JH

更新日期：2019-05-23 00:00:00

abstract：:The low pathogenicity and replicative potential of HIV-2 are still poorly understood. We investigated whether HIV-2 reservoirs might follow the peculiar distribution reported in models of attenuated HIV-1/SIV infections, i.e. limited infection of central-memory CD4 T lymphocytes (TCM). Antiretroviral-naive HIV-2 infec...

journal_title：PLoS pathogens

authors： Samri A,Charpentier C,Diallo MS,Bertine M,Even S,Morin V,Oudin A,Parizot C,Collin G,Hosmalin A,Cheynier R,Thiébaut R,Matheron S,Collin F,Zoorob R,Brun-Vézinet F,Autran B,ANRS CO5 IMMUNOVIR-2 Study Group.

更新日期：2019-05-16 00:00:00

abstract：:Memory T cell inflation is a process in which a subset of cytomegalovirus (CMV) specific CD8 T cells continuously expands mainly during latent infection and establishes a large and stable population of effector memory cells in peripheral tissues. Here we set out to identify in vivo parameters that promote and limit CD...

journal_title：PLoS pathogens

authors： Baumann NS,Welten SPM,Torti N,Pallmer K,Borsa M,Barnstorf I,Oduro JD,Cicin-Sain L,Oxenius A

更新日期：2019-05-13 00:00:00

abstract：:Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known. We generated replication-competent, FAST protein-deficient pteropine orthoreov...

journal_title：PLoS pathogens

authors： Kanai Y,Kawagishi T,Sakai Y,Nouda R,Shimojima M,Saijo M,Matsuura Y,Kobayashi T

更新日期：2019-04-25 00:00:00

abstract：:Infectious complications are a common cause of morbidity and mortality in cancer patients undergoing chemotherapy due to increased risk of oral and gastrointestinal candidiasis, candidemia and septicemia. Interactions between C. albicans and endogenous mucosal bacteria are important in understanding the mechanisms of ...

journal_title：PLoS pathogens

authors： Bertolini M,Ranjan A,Thompson A,Diaz PI,Sobue T,Maas K,Dongari-Bagtzoglou A

更新日期：2019-04-22 00:00:00

abstract：:Knowledge of the within-host frequencies of resistance-associated amino acid variants (RAVs) is important to the identification of optimal drug combinations for the treatment of hepatitis C virus (HCV) infection. Multiple RAVs may exist in infected individuals, often below detection limits, at any resistance locus, de...

journal_title：PLoS pathogens

authors： Raja R,Pareek A,Newar K,Dixit NM

更新日期：2019-04-01 00:00:00

abstract：:RsaE is a conserved small regulatory RNA (sRNA) which was previously reported to represent a riboregulator of central carbon flow and other metabolic pathways in Staphylococcus aureus and Bacillus subtilis. Here we show that RsaE contributes to extracellular (e)DNA release and biofilm-matrix switching towards polysacc...

journal_title：PLoS pathogens

authors： Schoenfelder SMK,Lange C,Prakash SA,Marincola G,Lerch MF,Wencker FDR,Förstner KU,Sharma CM,Ziebuhr W

更新日期：2019-03-14 00:00:00

abstract：:Eradication of tuberculosis (TB), the world's leading cause of death due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large-scale efficacy trials due to limited global resources. We aimed to pe...

journal_title：PLoS pathogens

authors： Rodo MJ,Rozot V,Nemes E,Dintwe O,Hatherill M,Little F,Scriba TJ

更新日期：2019-03-04 00:00:00

abstract：:Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass viral escape by their robust type I interferon pr...

journal_title：PLoS pathogens

authors： Assil S,Futsch N,Décembre E,Alais S,Gessain A,Cosset FL,Mahieux R,Dreux M,Dutartre H

更新日期：2019-02-28 00:00:00

abstract：:Several naked virus species, including members of the Picornaviridae family, have recently been described to escape their host cells and spread infection via enclosure in extracellular vesicles (EV). EV are 50-300 nm sized lipid membrane-enclosed particles produced by all cells that are broadly recognized for playing ...

journal_title：PLoS pathogens

authors： van der Grein SG,Defourny KAY,Rabouw HH,Galiveti CR,Langereis MA,Wauben MHM,Arkesteijn GJA,van Kuppeveld FJM,Nolte-'t Hoen ENM

更新日期：2019-02-19 00:00:00

abstract：:Extracellular signaling is a mechanism that higher eukaryotes have evolved to facilitate organismal homeostasis. Recent years have seen an emerging interest in the role of secreted microvesicles, termed extracellular vesicles (EV) or exosomes in this signaling network. EV contents can be modified by the cell in respon...

journal_title：PLoS pathogens

authors： McNamara RP,Chugh PE,Bailey A,Costantini LM,Ma Z,Bigi R,Cheves A,Eason AB,Landis JT,Host KM,Xiong J,Griffith JD,Damania B,Dittmer DP

更新日期：2019-02-04 00:00:00

abstract：:Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death lig...

journal_title：PLoS pathogens

authors： Holokai L,Chakrabarti J,Broda T,Chang J,Hawkins JA,Sundaram N,Wroblewski LE,Peek RM Jr,Wang J,Helmrath M,Wells JM,Zavros Y

更新日期：2019-01-31 00:00:00

abstract：:Many bacterial pathogens and symbionts use type III secretion machines to interact with their hosts by injecting bacterial effector proteins into host target cells. A central component of this complex machine is the cytoplasmic sorting platform, which orchestrates the engagement and preparation of type III secreted pr...

journal_title：PLoS pathogens

authors： Lara-Tejero M,Qin Z,Hu B,Butan C,Liu J,Galán JE

更新日期：2019-01-22 00:00:00

abstract：:The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflammatory response elicited by the parasite while tunnelling through intes...

journal_title：PLoS pathogens

authors： Duque-Correa MA,Karp NA,McCarthy C,Forman S,Goulding D,Sankaranarayanan G,Jenkins TP,Reid AJ,Cambridge EL,Ballesteros Reviriego C,Sanger Mouse Genetics Project.,3i consortium.,Müller W,Cantacessi C,Dougan G,Grencis RK,Ber

更新日期：2019-01-14 00:00:00